What is a lims and why is it essential for gene labs

A Laboratory Information Management System (LIMS) is software that orchestrates laboratory workflows and data. In genomics, it tracks samples from accessioning through extraction, library prep, sequencing, analysis, interpretation, and reporting. Key functions include barcoding and chain-of-custody, plate and batch management, instrument integration (for automatic data capture), reagent lot tracking, QA/QC checkpoints, role-based access, and audit trails. For clinical labs, a LIMS underpins CLIA/CAP compliance by enforcing SOPs, version control, competency documentation, and electronic records integrity (e.g., 21 CFR Part 11 considerations). It also bridges wet and dry labs by triggering pipelines and capturing run metrics alongside sample metadata, enabling traceability and retrospective review. Integration with EHR/LIS via HL7/FHIR supports result delivery and feedback loops. Without a LIMS, error rates and turnaround times increase, and regulatory evidence becomes difficult to produce. Selecting a LIMS requires mapping current and future workflows, data volume, integration points, and validation burden, with an implementation plan for configuration management and user training. Key Takeaway: LIMS is the backbone of traceability, compliance, and efficiency across wet and dry genomics workflows.